How Different Companies Developed a Covid-19 Vaccine - Do we Need to Get a Booster Shot?
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The highly transmissible omicron variant of the coronavirus has taken over as the dominant strain in the United States, resulting in breakthrough infections among the vaccinated. Omicron has sparked alarm both internationally and in the United States, where it accounted for more than 98 percent of new infections during the week ending Jan. 8, according to the most recent data from the Centers for Disease Control and Prevention. The variant has an unusually high number of mutations that make it significantly more contagious and capable of eluding the body’s first line of immune defenses 

 

 

 

For those of us lucky enough to live in wealthy countries with access to these top-shelf vaccines, it has made all the difference. The miracle workers behind the COVID-19 vaccines are the TIME Heroes of the Year not only because they gave the world a defense against a pathogen, but also because the manner of that astonishing achievement guards more than our health: they channeled their ambitions to the common good, talked to one another and trusted in facts.

 

 

Omicron Variant – NEW COVID Variant Worse Than Delta?   The Omicron variant just might be the scariest version of COVID yet. The WHO just announced that this SARS-CoV-2 coronavirus, B.1.1.529, has been elevated to a "variant of concern." The 3 things about Omicron that make it SUPER concerning:

 

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1. The specific mutations on the spike protein

2. The number of mutations in this virus

3. The fact that this FASTEST spreading COVID Variant

 

Omicron variant First case reported in Canada

Omicron Variant First Case Reported in Canada on November 28, 2021

 

The Covid Omicron variant emerged in South Africa. It was first discovered by scientists a few days ago. It has over 30 mutations on the spike protein that raise concerns that it might be more contagious, possibly cause more severe infection, and might evade our vaccines. This is not known for sure, but there is a HIGH level of concern, mainly because of how FAST this virus is spreading there. The question is, will our vaccines still be effective against the Omicron variant? That was the concern when Delta came out, and thankfully, our vaccines remain effective against Delta. But Delta doesn't have the same number of mutations as Omicron, and the big FEAR this virus evading our immune system might come true. I mean, we've had new variants emerge. We have seen many variants pop up over the last 8 months, and most of them, for example, Lamda, have not amounted to much. I mean, you hear about these new variants emerging all the time. They're expected. And they're detected because scientists are constantly running surveillance on COVID.  But here we are with the new one, Omicron. It has a certain level of concern, not just because it has MORE mutations in its spike protein, over 30 mutations, but also because some of those mutations are the SAME mutations as the other 4 variants of concern. But we won't really know if this variant will escape our vaccines until probably a few weeks from now because it takes time to do these studies.

 

rates of vaccinaded and non vaccinated cases and deaths

 

Coronavirus in the U.S.: Latest Map and Case Count   -   Updated Daily

Compared with the unvaccinated, fully vaccinated people overall had a much lower chance of testing positive for the virus or dying from it, even through the summer’s Delta surge and the relaxation of pandemic restrictions in many parts of the country. But the data indicates that immunity against infection may be slowly waning for vaccinated people, even as the vaccines continue to be strongly protective against severe illness and death.

 

Testing at Heathrow

 

The US will restrict travel from South Africa and seven other southern African countries to try to contain a new coronavirus variant spreading there.  Starting November 29, 2021, only US citizens and residents will be allowed to travel from the region. This follows a similar flight ban imposed by the EU and the UK. Canada is also introducing travel restrictions. The World Health Organization (WHO) earlier declared the new variant to be "of concern", naming it Omicron.

 

 

 

Do I need a COVID-19 booster shot? 6 questions answered on how to stay protected?

William Petri, Professor of Medicine, University of Virginia

Mon, August 16, 2021

 

coronavirus vaccine mix and match

 

The increasing prevalence of new coronavirus variants is raising questions about how well protected those who’ve already had their COVID-19 shots are against evolving forms of the SARS-CoV-2 virus. Here, microbiology and infectious disease specialist William Petri of the University of Virginia answers some common questions about COVID-19 booster shots.

 

COVID Busters 1

 

1. What is a booster shot?

Boosters are an extra dose of a vaccine given to maintain vaccine-induced protection against a disease. They are commonly used to bolster many vaccines because immunity can wear off over time. For example, the flu vaccine needs a booster every year, and the diphtheria and tetanus vaccineevery 10 years.

Boosters are often identical to the original vaccine. In some cases, however, the booster shot has been modified to enhance protection against new viral variants. The seasonal flu vaccine, most notably, requires an annual booster because the flu virus changes so rapidly.

 

2. Do I need to get a COVID-19 booster?

Only if you’re immunocompromised. As of August 2021, the U.S Food and Drug Administration and Centers for Disease Control and Preventionrecommend adding a third shot to the normal vaccination course for people who are severely immunocompromised.

 

3. Why aren’t booster shots recommended for everyone yet?

While vaccine-induced immunity may not last forever, it is not clear when a booster will be needed.    Encouragingly, all of the currently authorized COVID-19 vaccines induce a robust immune memory against the coronavirus. The vaccine teaches your immune system’s memory B cells to produce antibodies when you’re exposed to the virus. Researchers have detected high levels of memory B cells in the lymph nodes of people who received the Pfizer vaccine for at least 12 weeks after they got the shot.  Studies also suggest that authorized COVID-19 vaccines are continuing to offer protection even against emerging strains of the coronavirus. Among one study’s participants, the Johnson & Johnson vaccine had 73% and 82% efficacy 14 days and 28 days post shot, respectively, at warding off severe disease from the beta variant. Another study found the Pfizer vaccine to be 88% effective against the delta variant. The other source of long-lasting antibody responses against the coronavirus is cells called plasmablasts that reside in bone marrow. These cells continuously produce antibodies and do not require boosting to maintain their activity. Fortunately, plasmablasts have been detected in the bone marrow of people who received the COVID-19 vaccine for up to 11 months, indicating some degree of long-lasting immune memory.

 

4. How will I know if I need a booster?

You may need to wait for an outbreak in people who have been vaccinated. Researchers are still figuring out the best way to measure the strength of someone’s vaccine-induced immunity. The COVID-19 vaccines have been so effective that there are not many failures to test. The best candidate to measure are certain antibodies the vaccine induces the immune system to make. They recognize the spike protein that allows the coronavirus to enter and infect cells. Evidence supporting the importance of anti-spike antibodies includes a study showing that the somewhat more effective mRNA vaccines like Pfizer and Moderna generate higher antibody levels in the blood than the adenovirus vector vaccines like Johnson & Johnson and AstraZeneca. In a preliminary study that has not yet been peer-reviewed, anti-spike antibody levels were lower in people who caught COVID-19 after they were vaccinated with the Oxford–AstraZeneca vaccine.

Medical workers would love to be able to give patients a blood test that would tell them how well protected they are or aren’t against COVID-19. That would be a clear indication as to whether a booster shot is needed. But until researchers know for sure how to measure vaccine-induced immunity, the next indication that boosters may be needed are breakthrough infections in older adults who have already been vaccinated. People over the age of 80 make lower levels of antibodies after vaccination, so their immunity may wane sooner than that of the general population. The elderly would also most likely be the most susceptible to new viral variantsthat evade the protection current vaccines provide.

 

5. Who does the FDA and CDC recommend get a third shot?

An extra shot may be necessary for certain immunocompromised people. In one study, 39 of 40 kidney transplant recipients and a third of dialysis patients failed to make antibodies after vaccination. Another study identified 20 patients with rheumatic or musculoskeletal diseases on medications that suppress the immune system who also did not have detectable antibodies. Both of these studies were done after patients received the full vaccine dose.Currently, the CDC recommends that the following people consider getting a third dose:

 

  • People in active cancer treatment
  • People who have received organ transplants and are taking immunosuppressive therapy
  • People who have received a stem cell transplant within the past two years or are taking immunosuppressive therapy
  • People with moderate or severe primary immunodeficiency
  • People with advanced or untreated HIV infection
  • People taking high-dose corticosteroids and other immunosuppressive drugs

 

A third dose has been shown to help in these cases. In one study, one-third of solid organ transplant patients who had a suboptimal response to two doses of the Pfizer or Moderna vaccines were able to develop an antibody response with a third dose. Those who are immunocompromised may wonder if the vaccine they received is successfully generating immunity in their body. A preliminary study that has not yet been peer-reviewed did find that a test that specifically targets the anti-spike antibodies the vaccines trigger may be helpful in determining whether the vaccine worked. But for now, the FDA does not recommend antibody tests to assess immunity.

 

6. Does my third dose need to match my first two?

Likely not. Recent research has shown that mRNA vaccines, like Pfizer and Moderna, can be mixed with adenovirus-based vaccines like AstraZeneca with comparable results.

 

 

New Approach to Vaccines:

 

mRNA vaccines are a new type of vaccine to protect against infectious diseases. To trigger an immune response, many vaccines put a weakened or inactivated germ into our bodies. Not mRNA vaccines. Instead, they teach our cells how to make a protein—or even just a piece of a protein—that triggers an immune response inside our bodies. That immune response, which produces antibodies, is what protects us from getting infected if the real virus enters our bodies.

 

A Closer Look at How COVID-19 mRNA Vaccines Work:

 

COVID-19 mRNA vaccines give instructions for our cells to make a harmless piece of what is called the “spike protein.” The spike protein is found on the surface of the virus that causes COVID-19.

 

First, COVID-19 mRNA vaccines are given in the upper arm muscle. Once the instructions (mRNA) are inside the immune cells, the cells use them to make the protein piece. After the protein piece is made, the cell breaks down the instructions and gets rid of them.  

 

Next, the cell displays the protein piece on its surface. Our immune systems recognize that the protein doesn’t belong there and begin building an immune response and making antibodies, like what happens in natural infection against COVID-19.

 

At the end of the process, our bodies have learned how to protect against future infection. The benefit of mRNA vaccines, like all vaccines, is those vaccinated gain this protection without ever having to risk the serious consequences of getting sick with COVID-19.

 

COVID 19 mRNA infographic G 508 1

 

Pfizer and Moderna are likely to be the first companies to see their respective vaccines authorized in the United States at the end of 2020. Though their journeys to a COVID-19 vaccine have been eerily similar, the companies themselves could not be more different. Pfizer is a multinational pharmaceutical giant, while Moderna is a small biotechnology company that has never brought a drug to the market. Yet when the COVID-19 pandemic began, both companies bet big on a brand-new vaccine technology called mRNA. Moderna had been working on the technology for years, while Pfizer partnered with a smaller German biotechnology company BioNTech for its mRNA research.

 

 

USA Facts on Vaccinations

 

Click Here to See:  US Coronavirus Vaccine Tracker - Interactive

 

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Health Weather Alert:  Click Here to See the Interactive COVID-19 Risk by State and County

 

 

vaccines on world 1

 

 Vaccinating the world against COVID-19, which has killed more than 3.7 million people to date, is a monumental and complex task -- arguably, the biggest inoculation effort undertaken in history. In addition to developing safe and effective vaccines in record time, the logistics of rolling out those doses have been immense and raised questions about access and equity, specifically for poorer countries around the world and at-risk populations in the U.S. and elsewhere.  And experts say vaccinating the world is a matter of necessity, specifically vulnerable populations -- a key to reducing the burden on health systems and stemming the tide of contagious variants. The contrasts between haves and have-nots couldn't be starker -- while more than half the adults in the U.S. are fully inoculated much of the world lags behind. And as the U.S. struggles with unused doses of vaccines and hesitancy, some countries, such as India, Nepal, South Africa and those in South America are facing staggering outbreaks and losses.  Worldwide, more than 1.98 billion COVID-19 single vaccine doses have been administered, according to Our World in Data, but that does not account for the two doses required in many cases nor does it always indicate where doses have been administered. With more than 7.7 billion people in the world, there remains a long way to go in the battle against COVID-19.

 

vaccines to tye world

 

President Biden Announced a  Historic Vaccine Donation: Half a Billion Pfizer Vaccines to the World’s Lowest-Income Nation.  500 million life-saving vaccines to be delivered by June of next year, including 200 million to be delivered by the end of 2021.  Donation will serve as the foundation for a coordinated effort by the world’s democracies to vaccinate people around the world

 

 

 

 

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The U.S. is the second-biggest producer, at 27%, but its bulk contracts with manufacturers keep doses produced in the U.S. from leaving.The global supply of the Pfizer/BioNTech vaccine is coming from the EU, which is exporting 48% of its production, vs. 0% from the U.S. according to Airfinity, a science information and analytics company.Moderna is using its European facilities to supply Canada with doses, because all doses produced at U.S. sites are going toward the 300 million the U.S. has purchased.  The Biden administration took a tentative first step last week, offering around 4 million total doses of the Oxford/AstraZeneca vaccine — which isn’t authorized for use in the U.S. — to Mexico and Canada. The administration has also pledged $4 billion to the global COVAX initiative and more still to help increase supplies to Asia. But it’s holding tight to virtually every dose produced in the U.S. "We're going to have excess supply," said Zeke Emanuel, vice provost for global initiatives at the University of Pennsylvania, who was a member of Biden’s coronavirus task force during the transition.

 

 

Pfizer declined an initial research investment from the US government’s Operation Warp Speed, a multibillion-dollar program to accelerate the development and distribution of COVID-19 vaccines. But Moderna has been partnered with the government from the start, enjoying a longstanding research collaboration with the National Institutes of Health, accepting $955 million in funding from the Biomedical Advanced Research and Development Authority (BARDA). Both companies have accepted Operation Warp Speed funding in exchange for a promise that the first 100 million doses of their respective vaccines will be delivered to the U.S. government.  And when it comes to their vaccines, both Pfizer and Moderna’s are quite similar.

 

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Days Left by Country Until Herd Immunity to Covid-19  is Reached Through Vaccinations Around the World 

 

 

 

“They’re using something called an mRNA technology, which is relatively new in vaccine development,” said Azra Behlim, senior director of pharmacy sourcing and program services at Vizient.

 

 

Compared to some other vaccine technologies, mRNA is a more delicate product, Behlim told ABC News, meaning it needs to be kept frozen for long term storage. Moderna’s vaccine can be kept in normal freezer temperatures, like the freezer you have at home. Pfizer’s vaccine, meanwhile, must be kept in a specialized ultra-cold freezer at -94 degrees Fahrenheit. Once thawed, the Moderna vaccine can be kept in a normal refrigerator for a month, while Pfizer’s can only be kept in a typical fridge for five days.

 

Covid virus image w needle 

 

“Some of those cold chain storage issues that the Pfizer vaccine brought up ... could be alleviated with [Moderna's] vaccine,” said Dr. Colleen Kelley, associate professor of medicine at Emory University School of Medicine and principal investigator for the Moderna study at the Ponce de Leon Center. “This is good news for places that may not have access to that ultra-cold storage,” said Kelley. That could include more rural parts of America.  Operation Warp Speed Vaccine Development Lead Dr. Matt Hepburn said, "the fridge-for-a-month distribution point we made really enables for a much more distributed model to get the vaccine out there, potentially for example in very rural areas."

 

 

But with limited supplies of each vaccine available at first, enough to vaccinate only 20 million Americans by the end of the year, experts agree the U.S. needs multiple vaccines to fight the pandemic. That includes not only Pfizer and Moderna's vaccine but also even more that are further behind in development.   Two other companies that received funding for clinical research from Operation Warp Speed -- AstraZeneca and Johnson & Johnson -- had brief setbacks when their late-stage trials were paused over safety concerns. But those trials are now back up and running and may have data available in the coming weeks and months. “We will not see the other side of this pandemic without an effective vaccine, and multiple effective vaccines,” Kelley said.

 

J and J vaccine FDA approved

FDA Advisory Panel Endorses Third Covid-19 Vaccine - Johnson & Johnson - for Emergency Use  - 2 26 2021

 

Johnson & Johnson’s one-dose COVID-19 vaccine appeared safe and effective in trials, the U.S. Food and Drug Administration said, paving the way for its approval for emergency use  on February 26, 2021.  The vaccine was 66% effective at preventing moderate to severe COVID-19 in a 44,000 person global trial, the FDA said in documents ahead of a Friday meeting of independent experts who will advise the agency on emergency authorization. New data provided by J&J to the FDA showed the vaccine was 64% effective at stopping moderate to severe cases of COVID-19 after 28 days in thousands of trial participants in South Africa where a worrying new variant has swept across the country.

 

Johnson Johnsons COVID 19 vaccine

 

Overall, the vaccine was 100% effective at stopping hospitalization 28 days after vaccination, compared with 85% at 14 days, and there were no COVID-19 deaths among those who received the shot rather than a placebo. J&J also said the data suggested its vaccine cut down on asymptomatic infections, which experts said was another sign COVID-19 vaccines may indeed stop transmission of the disease.

 

Vaccine 1

 

“Most encouraging to me were the data in South Africa,” said Paul Offit, director of the Vaccine Education Center at the Children’s Hospital of Philadelphia and a member of the FDA advisory committee that will make its recommendation on Friday. “That you could still get protection against medically attended illnesses - meaning hospitalization, ICU admission and deaths from that vaccine against the South African strain, I thought that was really encouraging.”

 

 

The vaccine is administered in a single dose and can be stored in normal fridges, in contrast to the Pfizer and Moderna shots which need two doses and must be kept in freezers.  The J&J vaccine is also considered essential in the global vaccination effort due to its routine storage requirements and is already being rolled out to 500,000 healthcare workers in South Africa. J&J said in documents submitted to the FDA that in a preliminary analysis of its trial, it found 16 cases of asymptomatic cases in the placebo group versus two in the vaccine group, or an 88% efficacy rate. While fighting asymptomatic infection was not the primary goal of the trial, which studied the vaccine’s ability to stop moderate to severe COVID-19, the reduction of asymptomatic cases implies the shot can also cut transmission of the disease.  “The data is consistent with the fact that these coronavirus vaccines, including the J&J vaccine, do have an impact which is significant on asymptomatic spread,” said Amesh Adalja, a senior scholar at the Johns Hopkins Center for Health Security.

 

covid ilustration and vaccine 1

 

However, he said some public health authorities may ask to see more robust data before being persuaded.  The effectiveness of the one-dose vaccine varied over time. In Brazil, where a similar variant to the one in South Africa is circulating, the vaccine was 66% after 14 days, rising to 68% at 28 days. In the United States, the effectiveness fell from 74% at 14 days to 72% two weeks later. Overall, only two vaccine recipients developed COVID-19 severe enough to need medical intervention after 14 days and that dropped to zero after 28 days. J&J has said it sees rising immunity from its vaccine until at least 28 days after injection. The drugmaker has said it expects sustained - or even improved - protection over time.

 

Covid CUp Bottles vaccines

 

SIDE EFFECTS:  Three vaccine recipients had severe side effects in the trial that were likely related to the vaccine, but the FDA said its analysis did not raise any specific safety concerns that would preclude issuance of an emergency use authorization. The FDA said the most common reactions were injection site pain at 48.6%, headache at 39%, fatigue at 38.2% and myalgia at 33.2%. Other side effects included a fever in 9% of participants and a high fever in 0.2% of those who received the vaccine. The regulator said one case of pericarditis, a heart disease, may have been caused by the vaccine. It said cases of a rare disorder, Guillain-Barre Syndrome, were unlikely to be related to the shot though data was insufficient to determine whether the vaccine had caused these side effects.

 

AstraZeneca Logo Coronavirus Vaccine

AstraZeneca’s U.S. Trial Shows Coronavirus Vaccine is 79 Percent Effective

 

Oxford researchers, who developed the easily transported $4 shot for the British-Swedish pharmaceutical giant AstraZeneca, said their coronavirus vaccine is “safe and highly effective, adding to previous trial data from the United Kingdom, Brazil and South Africa, as well as real-world impact data from the United Kingdom.”  An independent monitoring board combed through the data to look for any cases of blood clotting events similar to those that caused the vaccination effort to be suspended in many European countries. While vaccination was started again after a pause, it undermined confidence in the vaccine. The independent board found no suggestion that the vaccine carried an increased risk of clotting.  The trials included 32,449 adult participants in all age groups, most of them in the United States. The volunteers received either two standard doses of the Oxford-AstraZeneca vaccine or a placebo, at a four-week interval, the researchers said.

 

 

The company said in its release it will apply for emergency authorization from the Food and Drug Administration “in the coming weeks,” but a question that has emerged recently is whether the United States, which President Biden has promised will have enough vaccine for all adults by the end of May, will need the vaccine. Fauci said it was too soon to know how it would fit into the U.S. vaccine portfolio “The one thing that one can say for sure, that this is good for the world, because it’s a cheap vaccine. It’s got good results. They will likely be able to produce enough for a lot of different countries,” Fauci said.

 

AstraZeneca box

 

The Oxford researchers said that the Data and Safety Monitoring Board in the United States “reported no safety concerns among the participants receiving at least one dose of the vaccine.”The results were reported in a pair of brief news releases from the pharmaceutical company and the university scientists.  The drug company said, “vaccine efficacy was consistent across ethnicity and age. Notably, in participants aged 65 years and over, vaccine efficacy was 80%.” The U.S. government has preordered 300 million doses of the AstraZeneca vaccine.

 

AstraZeneca bottles in freezer

 

The FDA has already given emergency authorization to vaccines from U.S. firms Pfizer, with German partner BioNTech; Moderna; and Johnson & Johnson. The Pfizer-BioNTech and Moderna vaccines, which require two doses, have shown up to 95 percent efficacy against symptomatic covid-19. The Pfizer-BioNTech vaccine requires special handling and must be kept at especially cold temperatures in special freezers.

 

 

An Israeli-American pharmaceutical company is preparing to launch a Phase I clinical trial for what could become the world’s first oral COVID-19 vaccine. Oramed Pharmaceuticals Inc., a clinical-stage pharmaceutical company based on technology developed by Hadassah-University Medical Center, announced over the weekend a joint venture with Premas Biotech to develop a novel oral vaccine. Together they formed the company Oravax Medical Inc. The vaccine is based on Oramed’s “POD” oral delivery technology and Premas’s vaccine technology.

 


 

As Society Looks to Rebound from Covid-19 the Ideas and Resources we Need to Cope and

 

Succeed will Look Different Than Before

 

Society after covid 1

 

 

How will People Change and Grow in the Wake of the Pandemic?   As human beings, we all share the same sorrows, the same hopes, the same potential. The Covid-19 pandemic has reminded us how interdependent we are: what happens to one person can soon affect many others, even on the far side of our planet.  Therefore, it is up to all of us to try to cultivate peace of mind and to think about what we can do for others, including those that we never see. It is natural to feel worry and fear at a time when so many are suffering. But only by developing calmness and clear-sightedness can we help others and, in so doing, even help ourselves. In my own life, I have often found that it is the most difficult challenges that have helped me gain strength.  The current global health crisis also reminds us that what affects the human family has to be addressed by all of us. The solution to this, as to many other problems, especially concerning the environment, depends on international co-operation. Ultimately, if humanity is to thrive, we must remember that we are one.

 

In person mask free interactions seem like a thing of the past but will eventually return as the importance of face to face relationships has become very clear in past months 1

 

In-person, mask-free interactions seem like a thing of the past, but will eventually return, as the importance of face-to-face relationships has become very clear in past months.  Early in the Covid-19 pandemic, as countries jostled for test kits and protective equipment, global supply chains imploded, and low-income countries found themselves at the back of the queue. The World Health Organization (WHO), working with United Nations partners, developed a procurement platform. The region now has more than 750 laboratories able to test for the virus. However, many low-income African countries are still struggling with a distorted market and less than optimal testing rates.  Ensuring access to a Covid-19 vaccine is potentially an even greater challenge. The speed of vaccine development has been extraordinary and it’s likely that we will have a viable vaccine in record time.

 

Relationships continue to be strained as social distancing and lockdowns stretch into 2021 causing some experts to worry about loneliness stemming from isolation 1

 

Relationships continue to be strained as social distancing and lockdowns stretch into 2021, causing some experts to worry about loneliness stemming from isolation. The pandemic has ruptured work for millions of people across the globe, leading to a painful period of uncertainty and anxiety. Being able to work is central to many aspects of life: survival, capacity to contribute and achieve, social connections and self-determination. This crisis is exposing the impact of the lack of protections and support for working people, which is now painfully clear. Because of the porous safety net that has allowed so many people across the globe to experience food, housing and health insecurity, I believe that this moment offers an inflection point.

 

In addition to mental health challenges the pandemic has also revealed challenges in our systems and institutions which were already riddled with inequalities and problems 1 1

 

In addition to mental health challenges, the pandemic has also revealed challenges in our systems and institutions, which were already riddled with inequalities and problems.  Presently, however, the pandemic is undisputable, causing suffering and deaths across the world. The question then arises as to how this could happen, and various forms of fake news and unrealistic narratives have flourished, in social and other media. Some argue in favour of increased nationalism, blaming globalisation for the pandemic. Other arguments are also seen, such as ‘nature fights back’, providing ‘nature’ with social agency.  Rather than adhere to conspiracy theories, nationalism, mysticism or other kinds of anti-intellectual attitudes, we need to return to the core ideas of the Enlightenment, questioning all kinds of orthodoxies, political and religious, and emphasise the scientific method (to develop vaccines) and international collaboration (to disseminate the vaccination programs) as the only way out of the crisis.

 

Wellbeing and happiness need to be bigger priorities for everyone in society experts say 1

 

Wellbeing and happiness need to be bigger priorities for everyone in society, experts say.  Hidden behind face masks, distanced six feet apart, we are quite literally losing touch with one another – starved of the social connectivity and engagement that is the very marrow of urban civic life. We turn instead to the echo chambers of social media, immersing ourselves in a sad simulacrum of the city – a kind of subdivision in the ether where we encircle ourselves with only those who look and act and think the way we do.  Now the pandemic has revealed in stark relief what those of us who have studied economic inequality already knew: Covid-19 laid bare the vast network of underlying fragilities that continues to threaten the health and well-being of the United States. The latest economic research shows the many ways that high inequality – in incomes, wealth, and across firms – serves to obstruct, subvert, and distort the processes that lead to widespread improved economic well-being.

 

 

Travelling will likely be profoundly different for the foreseeable future experts say including wholl be able to travel and where theyll be able to do it 1

 

Travelling will likely be profoundly different for the foreseeable future, experts say, including who'll be able to travel and where they'll be able to do it.  In the travel game, it’s tough even to understand what’s going on in the present. Some countries (Australia) won’t let people out, other countries (America) won’t let people in, even when they’re coming from a place with a better virus story. Or you can leave (the UK) and go somewhere else (the list changes daily) only to find (typically at 4 a.m.) all sorts of restrictions on your return. None of this encourages travel, and it’s probably a safe bet that merely making the decision to head for the departure gate is going to be a fraught choice for some time to come.

 

Fewer planes are flying through the sky in the age of Covid and the ultimate fate of the travel industry remains unknown and hanging in the balance 1

 

Quite apart from dealing with the bureaucracy and rules, I’m afraid that post-pandemic travel will be to a very different new world. Will we be welcomed? Will we be safe? And can we afford it? It will be a sad new world if travel becomes something only for the rich and gap-year travel becomes a rite of passage that ceases to exist. Of course, a travel reassessment will give us the opportunity to tackle some of the industry’s inevitable drawbacks from a fresh perspective, but will we tackle overtourism and climate change, or just turn the power back on and hit restart?  Fewer planes are flying through the sky in the age of Covid, and the ultimate fate of the travel industry remains unknown and hanging in the balance.

 

Urban living may be replaced with remote work in suburban or rural areas. But the city dwellers to stay put will grapple with continued Covid underscored inequalities 1

 

Urban living may be replaced with remote work in suburban or rural areas. But the city dwellers to stay put will grapple with continued, Covid-underscored inequalities.  Without a doubt, the ways we used to explore and engage while travelling have changed drastically. As we are now living with Covid, it is imperative that destinations, hotels, attractions, airlines – really the entire global tourist industry – continuously innovate solutions to meet the needs of “Gen-C”, the post-Covid generation. Our communal experience is driving changes to lifestyle and safety requirements for the new way of travelling.  At the forefront is restoring traveller confidence and communicating how adjustments are impacting travel experiences at the local level. The heart of this is creating and marketing experiences that lend to stress-free travel within this new world.

 

covid remote working 1

 

The biggest unknowns in a post-pandemic work world.  It’s been nearly a year since the novel coronavirus began spreading around the world. While we’ve learned a lot about Covid-19 since January – and how to live and work in lockdown – there’s still much we don’t know about how the pandemic will change our societies.  What Covid-19 has brought “is a mindset difference that allows people to view remote work as a new normal rather than an occasional opportunity”.

 

Covid 19 may have permanent effects 1 1

 

Covid-19 will likely have permanent effects on the way we work. But the way we live, socialise and move about the world will be different, too.  Covid-19 is a test like no other. Never before have the lives of so many people around the world been affected at this scale or speed. Over the past six months, thousands of AI innovations have sprung up in response to the challenges of life under lockdown. Governments are mobilising machine-learning in many ways, from contact-tracing apps to telemedicine and remote learning. However, as the digital transformation accelerates exponentially, it is highlighting the challenges of AI. Ethical dilemmas are already a reality – including privacy risks and discriminatory bias.

 


 

AstraZeneca

 

This undated file photo issued by the University of Oxford, shows of vial of coronavirus vaccine developed by AstraZeneca and Oxford University, in Oxford, England. Britain has authorized use of a second COVID-19 vaccine, becoming the first country to greenlight an easy-to-handle shot that its developers hope will become the “vaccine for the world.” The United Kingdom government says the Medicines and Healthcare Products Regulatory Agency has made an emergency authorization for the vaccine developed by Oxford University and UK-based drugmaker AstraZeneca. (John Cairns/University of Oxford via AP, File)

 

injecting

 

Britain on December 30, 2020,  became the first country to authorize an easy-to-handle COVID-19 vaccine whose developers hope it will become the “vaccine for the world.” The approval and a shift in policy that will speed up rollout of the vaccine in the U.K. come as a surge in infections threatens to swamp British hospitals. The Department of Health said it had accepted a recommendation from the Medicines and Healthcare Products Regulatory Agency to authorize emergency use of the vaccine developed by Oxford University and U.K.-based drugmaker AstraZeneca. “The rollout will start on Jan. 4 and will really accelerate into the first few weeks of next year,” British Health Secretary Matt Hancock told told Sky News. Britain has bought 100 million doses of the vaccine.

 

blood Testing as part of the AstraZeneca Procedure of testing

 

AstraZeneca chief executive Pascal Soriot told BBC Radio 4 the company could start shipping the first doses of the vaccine Wednesday or Thursday “and the vaccination will start next week and we will get to 1 million — and beyond that — a week, very rapidly.” Hundreds of thousands of people in the U.K. have already received a different vaccine, made by U.S. drugmaker Pfizer and German firm BioNTech. Soriot said it was “an important day for millions of people in the U.K. who will get access to this new vaccine. It has been shown to be effective, well-tolerated, simple to administer and is supplied by AstraZeneca at no profit.”

 

Oxford Institute in England

Oxford Institute - England

 

Coronavirus vaccines have typically been given in two doses, with an initial shot followed by a booster about three weeks later. But in a change of approach, the British government said that with the AstraZeneca vaccine it would prioritize giving as many people as possible a single dose, which is believed to give a large measure of protection against the virus. It said people at the highest risk would get priority, and everyone would get a second jab within 12 weeks of the first.The new strategy comes against a backdrop of soaring infections in the U.K. The number of hospitalized COVID-19 patients has surpassed the first peak of the outbreak in the spring, with authorities blaming a new, more transmissible variant of the virus, first identified in southeast England, for the spike.Oxford University’s Dr. Andrew Pollard, one of the leaders of the development team, offered hope the newly approved vaccine will help. “At the moment, there’s no evidence that the vaccines won’t work against the new variant,” Pollard told Radio 4. “But that is something which we have to look at. We can’t be complacent about this variant or perhaps future variants.”Partial results from studies in almost 24,000 people in Britain, Brazil and South Africa suggest the shots are safe and about 70% effective for preventing illness from coronavirus infection. That’s not as good as some other vaccine candidates, but Soriot recently told the Sunday Times newspaper that he was confident the vaccine would prove as effective as its rivals.

 

Researching AstraZenica

 

The Oxford-AstraZeneca vaccine is expected to be relied on in many countries because of its low cost, availability and ease of use. It can be kept in refrigerators rather than the ultra-cold storage some other vaccines require. The company has said it will sell it for $2.50 a dose and plans to make up to 3 billion doses by the end of 2021. “We have a vaccine for the world,” said Pollard. Researchers claim the vaccine protected against disease in 62% of those given two full doses and in 90% of those initially given a half dose because of a manufacturing error. However, the second group included only 2,741 people — too few to be conclusive. Questions also remain about how well the vaccine protects older people. Only 12% of study participants were over 55 and they were enrolled later, so there hasn’t been enough time to see whether they develop infections at a lower rate than those not given the vaccine. Researchers also were criticized for lack of information in September, when studies were suspended because a participant suffered a serious illness. AstraZeneca initially declined to provide further details due to patient confidentiality.

 

AstraZeneca Logo Coronavirus Vaccine

 

Ultimately, the trials resumed after regulators reviewed safety data and decided it was safe to continue. Published partial results show no hospitalizations or severe disease among those who received the vaccine. A separate study testing the AstraZeneca vaccine in the U.S. also is underway. The vaccine will become the second COVID-19 vaccine in use in Britain. On Dec. 2, regulators gave emergency authorization to the Pfizer-BioNTech vaccine. Having another vaccine available means that more people can get protection, said Sarah Gilbert, an Oxford scientist involved in the AstraZeneca project. It takes a different approach than the Pfizer-BioNTech one or another developed in the United States from Moderna Inc. The ultra-cold storage those other vaccines need is “very impractical” in developing countries, said Dr. Gillies O’Bryan-Tear, chair of policy and communications for Britain’s Faculty of Pharmaceutical Medicine. It means the AstraZeneca one “may reach more parts of the world than the Pfizer one,” he said. Britain’s action likely means the World Health Organization will soon clear the AstraZeneca vaccine for use in a global effort to help poor countries, called COVAX. The initiative, led by WHO and the vaccines alliance GAVI, has secured access to at least 100 million doses of the vaccine, with options and other deals to buy more. But none can be distributed until green-lighted by WHO.

 

vaccines on world 1

 

The U.N. health agency does not licence or regulate vaccines itself, but typically evaluates vaccines once they have been approved by an agency such as the U.K. regulator or the European Medicines Agency. WHO experts conduct their own evaluation of whether or not the risks of a vaccine outweigh its benefits and then make a recommendation for the shots to be “pre-qualified” so they can be bought by donors for developing countries. Most coronavirus vaccines to be used in poorer countries likely will be made by the Serum Institute of India, which has been contracted by AstraZeneca to make 1 billion doses. In June, the pharmaceutical company announced that the Serum Institute would produce 400 million doses by the end of 2020 but as of early December, only about 50 million doses had been manufactured after production was halted several times. In addition to the Serum Institute, AstraZeneca also has deals with vaccine makers in Brazil, South Africa and China to make the Oxford-developed vaccine for use in developing countries.

 

bottles of astrazeneca